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I 2019 udgav Sundhedsstyrelsen en nationwide klinisk retningslinje (NKR) for opioidbehandling af kroniske nonmaligne smerter [thirteen] (Tabel 1) og i samarbejde med Danske Regioner en ny smerteguide [14]. I begge peges der på, at der skal tages individuelle hensyn, og at opioidbehandling kan anvendes til de undergrupper af patienter med smerter,